Peer-reviewed Publications

2025

🔗 Association between choroidal microvasculature in the eye and Alzheimer’s disease risk in cognitively healthy midlife adults

Burke J, Gibbon S, Low A, Hamid C, Reid-Schachter M, Muniz-Terrera G, Ritchie CW, Dhillon B, O’Brien JT, MacCormick IJC, MacGillivray TJ.
Alzheimer’s Dement.

2024

🔗 The PREVENT Dementia programme: Baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

Ritchie CW, Bridgeman K, Gregory S, O’Brien JT, Danso SO, Dounavi ME, Carriere I, Driscoll D, Hillary R, Koychev I, Lawlor B, Naci L, Su L, Low A, Mak E, Malhotra P, Manson J, Marioni R, Murphy L, Stewart W, Muniz-Terrera G, & Ritchie K.
Brain Commun.

🔗 The Mediterranean diet is not associated with neuroimaging or cognition in middle-aged adults: a cross-sectional analysis of the PREVENT Dementia Programme

Gregory S, Buller-Peralta I, De La Cruz Góngara V, Dounavi ME, Low A, Ntailianis G, Parra M, Ritchie CW, Ritchie K, Shannon OM, Stevenson EJ, Wells K, Muniz-Terrera G.
Eur J Neurol.

🔗 Comprehensive allostatic load risk index is associated with increased frontal and left parietal white matter hyperintensities in mid-life cognitively healthy adults

Buller-Peralta I, Gregory S, Low A, Dounavi ME, Wells K, Ntailianis G, Lawlor B, Naci L, Koychev I, Malhotra P, O’Brien JT, Ritchie CW, Muniz-Terrera G.
Sci Rep.

🔗 Apoe ε4 exacerbates age-dependent deficits in cortical microstructure in midlife adults

Mak E, Dounavi ME, Operto G, Ziukelis E, Jones PS, Low A, Swann P, Newton C, Terrera-Muniz G, Malhotra P, Koychev I, Falcon C, Mackay C, Lawlor B, Naci L, Wells K, Ritchie C, Ritchie K, Su L, Gispert JD, O'Brien JT.
Brain Comms.

🔗 Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT-Dementia study

Gibbon S, Low A, Hamid C, Reid-Schachter M, Muniz-Terrera G, Ritchie CW, Trucco E, Dhillon B, O'Brien JT, MacGillivray TJ.
Alzheimers Dement.

🔗 Immune regulation and blood–brain barrier permeability in cerebral small vessel disease: study protocol of the INflammation and Small Vessel Disease (INSVD) study – a multicentre prospective cohort study

Low A, van Winden S, Cai L, Kessels RPC, Maas MC, Morris R, Nus M, Tozer DJ, Tuladhar AM, van der Kolk A, Wolters R, Mallat Z, Riksen NP, Markus HS, de Leeuw FE.
BMJ Open.
Co-first authorship.

🔗 Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study

Low A, McKiernan E, Prats-Sedano MA, Carter SF, Stefaniak JD, Su L, Dounavi ME, Muniz-Terrera G, Jenkins N, Bridgeman K, Ritchie K, Lawlor B, Naci L, Malhotra P, Mackay C, Koychev I, Thayanandan T, Raymont V, Ritchie CW, Stewart W, O’Brien JT.
JAMA Netw Open.
Scientific American Article.

2023

🔗 Artificial intelligence for diagnosis and prognosis in neuroimaging for dementia; a systematic review

Borchet R, Azevedo T, Badhwar A, Bernal J, Betts M, Bruuffaerts R, Bukhart M, Dewachter L, Gellersen H, Low A, …, Newby D, Ranson J, Llewellyn D, Veldsman M, Rittman T.
Alzheimer’s Dement.

🔗 Differential association of cerebral blood flow and anisocytosis in APOE ε4 carriers at midlife

Dounavi ME, Mak E, Swann P, Low A, Muniz-Terrera G, McKeever A, Pope M, Williams G, Wells K, Lawlor B, Naci L, Malhotra P, MacKay C, Koychev I, Ritchie K, Su L, Ritchie C, O’Brien J.
J Cereb Blood Flow Metab.

2022

🔗 Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia

Dounavi ME, Newton C, Jenkins N, Mak E, Low A, Muniz-Terrera G, Williams GB, Lawlor B, Naci L, Malhotra P, Mackay C, Koychev I, Ritchie K, Ritchie CW, Su L, O'Brien JT.
J Neurol.

🔗 Fluid-Attenuated Inversion Recovery MRI textural features as sensitive markers of white matter damage in midlife adults

Dounavi ME, Low A, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O'Brien JT.
Brain Commun.
co-first authorship

🔗 CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study

Low A, Prats-Sedano MA, Stefaniak JD, McKiernan EF, Carter SF, Dounavi ME, Mak E, Su L, Stupart O, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O'Brien JT.
J Neurol Neurosurg Psychiatry.

🔗 Modifiable and non-modifiable risk factors of dementia and midlife cerebral small vessel disease in cognitively healthy midlife adults: the PREVENT-Dementia study

Low A, Prats-Sedano M, McKiernan E, Carter S, Stefaniak JD, Nannoni S, Su L, Dounavi ME, Muniz-Terrera G, Ritchie K, Lawlor B, Naci L, Malhotra P, MacKay C, Koychev I, Ritchie CW, Markus HS, O’Brien JT.
Alz Res Therapy.

2021

🔗 Proximity to dementia onset and multi-modal neuroimaging changes: The PREVENT-Dementia Study

Mak E, Dounavi M, Low A, Carter SF, McKiernan E, Williams GB, Jones PS, Carriere I, Muniz-Terrera G, Ritchie K, Ritchie C, Su L, O’Brien JT.
NeuroImage.

🔗 Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: the PREVENT-Dementia study

Dounavi ME, Low A, McKiernan E, Mak E, Muniz-Terrera G, Ritchie K, Ritchie CW, Su L, O'Brien JT.
J Cereb Blood Flow Metab.

🔗 Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design

Brown R, Low A, Markus HS.
J Neurol Neurosurg Psychiatry.

🔗 Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study

Low A, Su L, Stefaniak JD, Mak E, Dounavi ME, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O'Brien JT.
Neurobiol Aging.

2020

🔗 Development and validation of a brief visual based cognitive screening tool for dementia: the Visual Cognitive Assessment Test short-form (VCAT-S)

Koh W, Lim L, Low A, Wong B, Lim L, Silva E, Ng KP, Kandiah N.
J Neurol Neurosurg Psychiatry.

🔗 Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment

Wong FCC, Yatawara C, Low A, Foo H, Wong BYX, Lim L, Wang B, Kumar D, Ng KP, Kandiah N.
Transl Stroke Res.

🔗 Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage

Low A, Mak E, Stefaniak JD, Malpetti M, Nicastro N, Markus HS, Rowe JB, O’Brien JT.
Front Neurosci.

🔗 In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease

Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB, Markus HS, O’Brien JT.
J Neurol Neurosurg Psychiatry.

2019

🔗 Construct Validity of the Visual Cognitive Assessment Test (VCAT): A Cross-Cultural Language-Neutral Cognitive Screening Tool

Low A, Lim L, Lim L, Wong B, Silva E, Ng KP, Kandiah N.
Int Psychogeriatr.

Predictors and Patterns of Cognitive Decline Differ between Mild Cognitive Impairment in Parkinson’s disease (PD-MCI) and Alzheimer’s disease (AD-MCI)

Low A, Yong T, Chandler RJ, Ng KP, Kandiah N.
J Alzheimers Parkinsonism Dement.

🔗 Hippocampal Subfield Atrophy of CA1 and Subicular Structures Predict Progression to Dementia in Idiopathic Parkinson’s disease

Low A, Foo H, Yong T, Tan LCS, Kandiah N.
J Neurol Neurosurg Psychiatry.

🔗 Asymmetrical Atrophy of Thalamic Subnuclei in Alzheimer’s Disease and Amyloid-Positive Mild Cognitive Impairment is Associated with Key Clinical Features

Low A, Mak E, Malpetti M, Chouliaras L, Nicastro N, Su L, Holland N, Rittman T, Vázquez Rodríguez P, Passamonti L, Bevan-Jones WR, Jones PS, Rowe JB, O'Brien JT.
Alzheimers Dement (Amst).

🔗 Association of Asymmetrical Distribution of White Matter Hyperintensities and Apolipoprotein E4 on Cognitive Outcomes in Mild Cognitive Impairment and Dementia

Low A, Ng KP, Chander RJ, Wong B, Kandiah N.
J Alzheimers Dis.

🔗 Inflammation and cerebral small vessel disease: A systematic review

Low A, Mak E, Rowe JB, Markus HS, O’Brien JT.
Ageing Res Rev.