About
I am a Research Fellow at the University of Cambridge (Old Age Psychiatry group, PI: John T O’Brien) studying the role of cerebrovascular dysfunction in dementia and cognitive impairment, with the help of multimodal neuroimaging techniques and clinical data in humans.
I am also interested in studying the early risk and resilience factors of dementia, and how cerebral small vessel disease is involved in early dementia pathogenesis. In particular, I am interested in how cerebral small vessel disease relates to established dementia risk factors and molecular imaging markers of dementia (e.g., amyloid, tau, neuroinflammation), as a way to further our understanding of how various pathologies interact in their contribution to neurodegeneration and clinical outcomes. Most recently, my research focuses on the associations between cerebral small vessel disease, inflammation, and blood brain barrier permeability.
On top of my academic work, I support younger researchers as the Early Career Investigator Representative of the International Society of Vascular Behavioural and Cognitive Disorders (VasCog).
Profiles
Research Interests
- Dementia
- Cerebral small vessel disease
- Inflammation
- Blood brain barrier
- Neuroimaging
- Cognition
Contact
Email: al927 [at] cam.ac.uk